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秦炯淙教授研究室招全额奖学金博士

2020-08-17 17:54:08

      Hyung Jong Jin


                         Wawoo-Ahngil 17, Bongdam-Eup

                         Whasung city, Kyunggi-Do 18323, Korea

                        

EDUCATION

             B.S. Pharmaceutics, 1982, Seoul National University

             M.S. Biochemistry, 1987, Seoul National University

             Ph.D. Biochemistry, 1991, Seoul National University

 

PROFESSIONAL EXPERIENCES

             Postdoctoral Research Associate, Department of Pharmacology, Medical

     School, University of Wisconsin-Madison, 1991-1994 (Biochemistry

      Molecular Biology of Erm protein, 23S rRNA methyltransferase)

Researcher, Department of Biochemistry Molecular Pathology, NEOUCOM, 1994-1996 (Biochemistry Molecular Biology of Leukotriene B4 ω-hydroxylase)

Permanent lecturer, Department of Bioscience Biotechnology, College of Natural Science, The University of Suwon, 1996-1998

Assistant professor, Department of Bioscience Biotechnology, College of Natural Science, The University of Suwon, 1998-2002

Associate professor, Department of Bioscience Biotechnology, College of Natural Science, The University of Suwon, 2002-2007

Professor, Department of Bioscience Biotechnology

     College of Natural Science, The University of Suwon, 2007-present

 

HONORS

             KOSEF postdoctoral Fellow (1991-1992)

             Marquis Whos Who in Science Engineering (2000-  )

             Marquis Whos Who in the World (2000-   )

             Marquis Whos Who in Medicine Healthcare (2000-  )

             IBC (International Biographical Centre) Top 1000 Educator, 2000 Outstanding Intellectuals of the 21st Century etc.

             The University of Suwon Best Research Award (2005 2010)

             ABI (American Biographical Institute) Sir ISAAC Newton Scientific Award of Excellence for 2012

 

INVITED LECTURES

 

             Lectures have been presented at the Fourth Symposium of Korean Applied Pharmacology Society on New Drug Development (Seoul, 1996); Yuhan corporation symposium on antibiotic resistance (Anyang, 1997); DongA Pharmaceutical Company New Drug  development symposium (Singal, 1997); Symposium for Genetic Engineering Research at Kyunghee University (Suwon, 1998); KIST New Drug  development symposium (Seoul, 1998); the 6th IUBMB  Conference (Seoul, 1998); KOSEF Symposium for RNA biotechnology (Daejeon, 1999); KBSI symposium on protein-RNA interaction (Daejeon, 2000); PIKE symposium on RNA methylation (Seoul, 2000); KOLON symposium for the new drug development (Yongin, 2001); Suwon  University symposium for protein research (Suwon, 2001); 2002 International Conference of The Biochemical Society of Korea (Seoul, 2002); Hanmi Symposium for drug development (Pangyo, 2002); 2003 spring symposium of Life chemistry section for The  Korean Chemical Society (Daejeon, 2003); The 91st Scientific meeting for The Korean Chemical Society (Seoul, 2003); RNA workshop 2003 (Anmyundo, 2003); KIAS symposium  on protein science (Seoul, 2003); ChoongNam National University Symposium (Daejeon, 2003); RNA 2004 International  Summer Symposium (Seoul, 2004); The 17th Annual Meeting of the Korean   Society for Molecular Cellular Biology (Seoul, 2005); RNA workshop 2006 (Busan, 2006); 12th symposium for Sogang BK21 Global leader program (Seoul, 2007); RNA workshop 2007 (Seoul, 2007); The 48th MSK annual meeting 2008 International symposium on Microbiology (Daejeon, 2008); RNA workshop 2008 (Busan, 2008); 1st drug development researchers association workshop (Seoul, 2009); RNA workshop 2009 (Yangyang, 2009); The 21st Annual Meeting of the Korean Society for Molecular Cellular Biology (Seoul, 2009); BIT's 8th Annual Congress of International Drug Discovery Science Technology (Beijing, 2010); 2010 KSBMB Annual Meeting (Seoul, 2010); 2011 Annual Symposium of the Korean RNA society (Moochangpo, 2011); 5th International Botanical Conference (Dhaka, 2011); 22nd IUBMB & 37th FEBS Congress, Seville, 2012); Dongwha Symposium for Drug Development. 2014 Dongwha Pharmaceutical Corporation Central Research Institute (Yongin, 2014); Dong-A Symposium for Drug Development (Yongin, 2014); ChoongNam National University Symposium (Daejeon, 2015), abbio symposium (Seoul, 2016); ChoongNam National University Symposium (Daejeon, 2018); Choongbuk National University Symposium (Ochang, 2019) 

 

SCIENTIFIC PUBLICATIONS

 

1.  Lee, S. S.,  H. J. Jin, Y. W. Sohn. (1987).  " Microbial p-hydroxylation of  aniline by Streptomyces: enzyme gene locus" in Recent Progress in Molecular  Biology Genetic Engineering of Korea eds. by the Institute for Molecular  Biology Genetics, SNU. pp 55-60  

 

2.  Lee, S. S., H. J. Jin, M. W. Sohn. (1987). "Microbial conversion of aniline to  acetaminophen" in Biochemistry for Development eds. by M. A. Rahman, pp 88-97

 

 3. Lee, S. S., H. J. Jin, S. I. Kim. (1988). "Microbial p-hydroxylation of aniline by  Streptomyces: Characterization of Genes" in Recent Progress in Molecular Biology  Genetic Engineering of Korea eds. by the Institute for Molecular Biology   Genetics, SNU. pp 63-68 

 

 4. Lee, S. S., H. J. Jin, A. K. Park. (1990). " Microbial synthesis of acetaminophen      acetanilide by Streptomyces fradiae" in Recent Progress in Molecular Biology   Genetic Engineering of Korea eds. by the Institute for Molecular Biology   Genetics, SNU. pp 89-96.  

 

5. Sang Sup Lee, Hyung Jong Jin. (1991). p-Hydroxylation of aniline   formation of acetaminophen in Streptomyces spp. J. Natl. Acad. Sci. Korea Natl. Sci.  series. 30. 123-161.

 

6. Sang Sup Lee, Hyung Jong Jin, Mi Won Sohn. (1992). Microbial transformation  of aniline to acetaminophen. Arch. Pharm. Res. 15(1). 30-34.

 

7. Hyung Jong Jin, Ae Kyung Park, Sang Sup Lee. (1992). Bioconversion of  aniline to acetaminophen overproduction of acetminophen by Streptomyces spp.  Arch. Pharm. Res. 15(1). 41-47.

 

8. Hyung Jong Jin, Ae Kyung Park, Sang Sup Lee. (1992). Genetic analysis on  bioconversion of aniline to acetaminophen in Streptomyces fradiae. Arch. Pharm.  Res. 15(1). 35-40.

 

9. Hyung Jong Jin, Ae Kyung Park, Sang Sup Lee. (1992). Enzymatic analysis of acetanilide p-hydroxylase in Streptomyces fradiae. Arch. Pharm. Res. 15(3). 215-219.

 

10. Hyung Jong Jin, David Kovalic, Robert Ginatassio, Bernard Weisblum. (1994). 23S rRNA domain V, a fragment that can be specifically methylated in vitro by the  ErmSF(TlrA) methyl transferase. J. Bacteriol. 176(22). 6992-6998.

 

11. Hyoung Jin Kwon, C. R. Hutchinson, Hyung Jong Jin, Soo Un Kim, Kye Joon Lee,  Joo Won Suh. (1995). Genetic analysis of polyketide biosynthesis genes isolated   Streptomyces albus, a salinomycin producer.  J. Microbiol. Biotech. 5(2). 74-79.

 

12. Hyoung Jin Kwon, C. R. Hutchinson, Hyung Jong Jin, Soo Un Kim, Kye Joon Lee,      Joo Won Sun. (1995). Nucleotide sequence analysis of the genes for type II polyketide synthase isolated Streptomyces albus. Kor. J. Appl. Microbiol.  Biotechnol. 23(2). 178-186.

 

13. Hyung Jong Jin. (1996). Streptomyces  E. coli cross-talk to each other through  ErmSF methyltransferase. J. of Nat. Sci. 5. 247-256.

 

14. Hyung Jong Jin. (1997). Chlamydia pneumoniae: A causative pathogen of heart  attack, stroke atherosclerosis?  Microorganism Industry 23(1). 25

15. Hyung Jong Jin. (1997). Analysis of human cytochrome P450 4F2 gene. J. of Nat.  Sci. 6. 183-190

 

16. Hyung Jong Jin. (1997). Characteristics of the human CYP 4F2 isolated Human

liver. Gen. Engineer. Res. 2. 85-94

    

17. Hyung Jong Jin. (1998). Isolation of human CYP 4F2 genomic DNA its 5' end  regulatory region structure. Arch. Pharm. Res. 21(1). 35-40

 

18. Young Duk Yang, Hak Jin Lee, Hyung Jong Jin. (1998). Overexpression of   ErmSF methyltransferase, MLS antibiotic resistance factor in E. coli its  interaction with 23S rRNA. Proc. Mol. Biol. & Genet. 13. 339-341.

 

19. Hyung Jong Jin. (1998). Antibiotic resistance: Past, present the future. Suwon   University J. 16. 305-315.

 

 20. Hyung Jong Jin. (1998). Refolded ErmSF inclusion body can successfully   methylates the E. coli 23S ribosomal RNA. Genet. Engineer. Res. 3. 201-206.

 

21. Hyung Jong Jin. (1999). ermSF, a ribosomal RNA adenine N6-methyltransferase gene Streptomyces fradiae, confers MLS(macrolide-lincosamide-streptogramin B)  resistance to E. coli when it is expressed. Mol. Cells. 9(3). 252-257.

 

22. Hak Jin Lee Hyung Jong Jin. (1999). Refolding Its Mechanism of ErmSF   Overexpressed as Inclusion Body in E. coli. Proc. Mol. Biol. & Genet. 14. 695-697

 

23. Yang Young Duk Hyung Jong Jin. (1999). Overexpression of ErmSF, MLS  (Macrolide-Lincosamide-Streptogramin B) Antibiotic Resistance Factor Protein as   Soluble Protein in E. coli  Identification of Minimalist Substrate Interaction  Mode with 23S rRNA through Site-Directed Mutagenesis. Proc. Mol. Biol. & Genet.  14. 269-272

 

24, Hyung Jong Jin (2000) Characterization of putative 27nt minimalist 23S rRNA   substrate for ErmSF,  MLS (macrolide-lincosamide-streptogramin B) antibiotic  resistance factor protein.  Suwon Univ. J. 18, 261-272

 

25. Hyung Jong Jin (2000) Studies on highly conserved amino acids 64S 65Q in  ErmSF 23S rRNA methyltransferase: site-directed mutagenesis, in vivo, in vitro  activity assay.  Suwon Univ. J. 18, 273-283

 

26. Hyung Jong Jin (2000) Studies on function of N-terminal end loop region of ErmSF     23S rRNA methyltransferase: in vivo, in vitro activity assay PACE analysis J.  Natl. Sci. 3, 143-155

 

28. Hyung Jong Jin (2000) Studies on interaction mode of ErmSF with 23S rRNA through    in vitro activity kinetic analysis J. Natl. Sci. 3, 156-171

 

29. Hyung Jong Jin, Young Duk Yang, Hak Jin Lee (2001) Recognition Sequence in  23S rRNA by ErmSF N-methyltransferase in Vitro. FASEB J. 15(4). 111

 

30. Hyung Jong Jin (2001) Domain expression of ErmSF, MLS (macrolide-lincosamide-streptogramin B) antibiotic resistance factor protein. Kor. J. Microbiol. 37. 2456-252.

 

31. Hyung Jong Jin (2001) Studies on highly conserved serine 64 in MLS antibiotic  resistance factor protein, ErmSF.  Suwon Univ. J. 19, 139-149

 

32. Hyung Jong Jin, Young Duk Yang (2002) Purification biochemical characterization of the ErmSF, MLS (macrolide-lincosamide-streptogramin B) resitance    factor protein expressed as a hexahistidine tagged protein in E. coli. Protein Express.  Purif. 25(1) 149-159.

 

33. Hyung Jong Jin (2002) Studies on N-terminal end region motif -60RRE62- in  ErmSF. Suwon Univ. J. 20, 183-194

 

34. Hak Jin Lee Hyung Jong Jin (2003) Renaturation of recombinant ErmSF its refolding behaviour. Mol. Cells 16(2) 187-193

 

35. Hyung Jong Jin (2003) Investigation of specific binding of ErmSF N-terminal end  region with substrate RNAs J. Natl. Sci. 2(2). 54

 

36. Hyung Jong Jin (2003) Overexpression of truncated ErmSF using lowered temperature,   various vectors cotransformation. Suwon Univ. J. 21, 163-174

 

37. Hyung Jong Jin (2003) Effect of dialysis methods on yield activity in ErmSF   refolding. Suwon Univ. J. 21. 175-185

 

38. Hak Jin Lee Hyung Jong Jin (2004) Deletion of N-terminal end region of ErmSF    leads to an amino acid important role in methyl transfer reaction. Kor. J.  Microbiol. 40(4) 257-262

 

39. Hyung Jong Jin (2004) The effect of secondary structure of rRNA on substrate activity   to ErmSF. Suwon Univ. J. 22.  85

 

40. Hyung Jong Jin (2004) The role of highly conserved F67 in enzymatic activity of  ErmSF, MLS antibiotic resistance factor protein Suwon Univ. J. 22, 95

 

41. Hyung Jong Jin (2004) Interaction mode of N-terminal end region of ErmSF with  stems 73-75 of 23S rRNA. J. Natl. Sci. 3(1) 21

 

42. Hyung Jong Jin (2004) Minimal substrate of ErmSF. J. Natl. Sci 3(1) 85

 

43. Hyung Jong Jin (2005) Kinetic studies of ErmSF 23S rRNA methyltransferase using   Domain V as substrate. J. Natl. Sci. 4(1). 54

 

44. Hyung Jong Jin (2005) Role of the motif, 60RRE62 of ErmSF in mono-, dimethylation by ErmSF. Suwon Univ. J. 23, 34

 

45. Hak Jin Lee Hyung Jong Jin (2005) Identification of amino acid in unstructured region of ErmSF which has crucial role in methyl group transfer reaction. FEBS J. 272 (1), 10

 

46. Hyung Jong Jin (2006) Functional role of peptide segment containing 1-25 amino acids in N-terminal end region of ErmSF. Kor. J. Microbiol. 42(3) 165

 

47. Hyung Jong Jin (2006) Studies on function of N-terminal end region of ErmSF, 23S rRNA methyltransferase. J. Natl Sci 5(1) 73

 

48. Hyung Jong Jin (2007) Studies on function of motif 60RRE62 in 23S rRNA methyltransferase ErmSF with deletion mutagenesis J. Natl. Sci 6(1) 103

 

49. Hyung Jong Jin (2007) Cloning of TlrD, 23S rRNA monomethyltransferase gene, overexpression in Escherichia coli its activity Kor. J. Microbiol. 43(3) 166

 

50. Hyung Jong Jin (2008) Functional role of 60RR61 in 23S rRNA methylation, which is in N-terminal end region of ErmSF. Korean J. Microbiol. 44(3), 193

 

51. Hak Jin Lee Hyung Jong Jin (2008) RRE motif in Erm, its role in 23S rRNA methylation based on structure its implication in drug development. FEBS J. 275(1) 167

 

52. Ae Kyung Park, Ho Kim Hyung Jong Jin (2009) Comprehensive analysis of evolutionary conserved rRNA adenine dimethyltransferase suggests diverse bacterial contributions to the nucleus-encoded plastid proteome. Mol. Phylogenet. Evol, 50(2) 282

 

53. Ae Kyung Park, Ho Kim Hyung Jong Jin (2010) Phylogenetic analysis of ribosomal RNA methyltransferases, Erm KsgA, as related to antibiotic resistance. FEMS letters 309(2) 151

   

54. Hyung Jong Jin (2011) Investigation on inhibitory effect of ErmSF N-terminal end region peptide on ErmSF methyltransferase activity in vivo through development of co-expression system of two different proteins in one cell Korean J. Microbiol. 47(3), 200

 

55. Hyung Jong Jin (2012) Site-directed mutagenesis analysis elucidates the role of 223/227 argine in 23S rRNA methylation, which is in target adenine binding loop region of ErmSF Korean J. Microbiol. 48(2) 79

 

56. Hyung Jong Jin Hak Jin Lee (2012) New erm gene in Bacillus halodurans C-125, alkaliphilic bacterium. FEBS J. 279(1) 565

 

57. Hyung Jong Jin (2013) Mutational analysis elucidates the role of conserved 237 arginine in 23S rRNA methylation, which is in the concave cleft region of ErmSF Korean J. Microbiol. 49(2) 105

 

58. Hyung Jong Jin Hak Jin Lee (2014) Effect of Truncation of 38 Amino Acids in N-Terminal End Region of ErmSF, a MLSB Antibiotic Resistance Factor Protein, on Enzymatic Activity Korean J. Microbiol. 50(3) 239

 

59. Tien Le, Hak Jin Lee Hyung Jong Jin (2015) An Efficient method to eliminate the protease activity contaminating commercial bovine pancreatic DNase I Analyt. Biochem. 483. 4

 

60. Hyung Jong Jin (2016) In vitro activity comparison of Erm proteins Firmicutes Actinobacteria. Korean J. Microbiol., 52(3) 269

 

61. Tien Le, Hak Jin Lee Hyung Jong Jin (2017) Recognition site generated by natural changes in Ermn proteins leads to unexpectedly high susceptibility to chymotrypsin ACS Omega 2(11), 8129

62. Hak Jin Lee, Young In Park, Hyung Jong Jin (2020) Plausible Minimal Substrate for Erm Protein. Antimicrob. Agents Chemother.

 

PATENT

 

Method for removing activity of contaminated proteins, proteolytic enzyme precursor, while maintaining DNase I activity, patent number 10-2015-0191846,    Korea

 

 

RESEARCH SUPPORT

 

KRF (Korean Research Foundation) Korean Ministry of Education

Molecular Biological Biochemical Research on Erm protein, 23S rRNA methyltransferase (1996-1999)

Genetic biochemical analysis of Leukotriene B4 ω-hydroxylase (1997-1998)

Functional role of amino acids in protein-RNA interaction in 23S rRNA methylation by Erm protein (2007-2008)

 

 

KOSEF (Korean Science Engineering Foundation)

Molecular biological analysis of Leukotriene B4 ω-hydroxylase (1998-1999)

Molecular Biological Biochemical Research on Erm protein, 23S rRNA methyltransferase (2000-2006)

Development of target site for Erm protein inhibitor (2008-2011)

 

MOHW(Mistry of Health Welfare)

Search for antibiotic resistance factor inhibitors to be coadmistered with antibiotics Korean traditional herb medicine(2011)

 

NRFK(National Research Foundation of Korea)

Functional role of nucleotides its network in 23S rRNA methylation by Erm (2010-2013)

Development of DNase I for reagents, diagnostics biopharmaceuticals through the characterization of DNase I(2018-2023)

 

 

KSMBA (Korea Small Medium Business Administration)

Simplification of manufacturing process purity improvement of DNase I(2015-2016)

 

INDUSTRIAL

Pacific Pharm. Co. Unrestricted research support.

 

SCIENTIFIC SOCIETY ACTIVITIES

 

Councilor, The Korean Society of Microbiology (1999- )

Member of advisory board of academic award, The Korean Society of Molecular Cellular Biology (2002-2010 )

Secretary General of Korean RNA society (2001-2005)

Vice President of Korean RNA Society (2005-2007)

President of Korean RNA Society (2007-2011 )

Member of delegation for The Korean Society of Molecular Cellular Biology (2010-2012)


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